Motilium (Domperidone)
What is Motilium
The antiemetic and gastroprokinetic medication known as domperidone, which is also commonly referred to as Motilium, is primarily employed for the treatment of nausea and vomiting. Through its action, it inhibits dopamine receptors in the gut, which in turn improves the motility of the gastrointestinal tract and makes it possible for the stomach to empty. The medication domperidone is sometimes used in the treatment of gastrointestinal conditions such as gastroparesis and nausea caused by chemotherapy. It is also sometimes used as a symptom reliever for other gastrointestinal diseases.
Recommendations
The usual adult dose is 10 mg, taken three to four times daily; the maximum daily dose is not more than 30 mg. Usually speaking, domperidone should be used before meals.
Swallow the tablets whole together with water. They should not be taken with food since this will influence absorption. Use only for short-term treatment (usually at most one week) unless expressly advised by a healthcare practitioner.
Precautions and Contraindications
● If you have a known hypersensitivity to Motilium or any component of this drug, do not use it.
● Patients with a history of cardiac arrhythmias or other heart disorders should exercise caution since Motilium has been linked to an elevated risk of QT interval prolongation and significant cardiac events.
● Gastrointestinal Diseases: Not advised for those with gastrointestinal diseases where higher gastrointestinal motility could be detrimental, such as gastrointestinal bleeding or perforation.
● Use carefully in people with liver impairment since it may raise their overall medication exposure.
● Contraindicated in patients with a prolactinoma—a form of pituitary tumor— Motilium raises prolactin levels.
● Safety has not been completely verified; hence, before taking it during pregnancy or while breastfeeding, see a healthcare professional.
Interactions
● Medications that block CYP3A4 (such as erythromycin and ketoconazole) raise plasma CYP3A4 levels, increasing the risk of Motilium (domperidone) toxicity; dosage changes may be required.
● Drugs That Increase QT Interval: Use carefully along with other medications that can extend the QT interval to prevent synergistic effects.
● Anticholinergic medications may affect Motilium's (domperidone) prokinetic action; track for loss of efficacy.
Side Effects
● Typical side effects are dry mouth, vertigo, headache, and stomach cramps.
● The potential for major cardiac arrhythmias resulting from QT prolongation should be considered, particularly in sensitive groups or at larger dosages.
● Rarely, particularly in youngsters or with extended use, neurological adverse effects like tremors or other extrapyramidal symptoms can develop.
● Rising prolactin levels could cause gynecomastia, menstruation abnormalities, or galactorrhea—milk production.
Before You Start Motilium Treatment
● Medical History: Give your doctor a thorough medical history, especially regarding cardiovascular health and any present drugs.
● Physical Examination: A complete physical examination may be required to ascertain whether domperidone is suitable for your ailment.
● Regular monitoring of heart function could be necessary, especially in groups at risk for cardiac adverse effects or if using greater doses.
Overdose
● An overdose may cause symptoms including confusion, disorientation, drowsiness, dizziness, or adverse effect aggravation, including arrhythmias.
● Action: See a doctor right away should an overdose be suspected. Usually, notably for cardiac symptoms, management consists of supportive care and monitoring.
Conclusion
When it comes to managing the use of Motilium (domperidone), it is essential to give careful consideration to its safety profile and regulatory guidelines. Motilium has the potential to be an effective treatment for certain gastrointestinal disorders. In order to receive individualized medical advice, you should always consult with a healthcare provider.